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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -CXCR7 (C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7, Chemokine Orphan Receptor 1, G-protein Coupled Receptor 159, G-protein Coupled Receptor RDC1 Homolog, RDC-1, CMKOR1, GPR159, RDC1) (APC)

Anti -CXCR7 (C-X-C Chemokine Receptor Type 7, CXC-R7, CXCR-7, Chemokine Orphan Receptor 1,
G-protein Coupled Receptor 159, G-protein Coupled Receptor RDC1 Homolog, RDC-1, CMKOR1,
GPR159, RDC1) (APC)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
CXCR7 (CXC chemokine receptor 7; also known as GPRN1, RDC-1, and chemokine orphan receptor 1) is a 60kD member of the G protein-coupled receptor 1 family. It is expressed on multiple cell types, including neurons, T cells, natural killer cells, neutrophils, and B cells, plus angiogenic endothelial cells. CXCR7 forms both homodimers and heterodimers with CXCR4. It selectively binds ITAC and SDF-1, and appears to involve B-arrestin 2 during signaling. Notably, a CXCR7:CXCR4 heterodimer shows increased responsiveness to SDF-1, and ITAC may actually block some SDF-1-mediated migration activity. Mouse CXCR7 is a seven transmembrane glycoprotein that is 362aa in length. It contains a 47aa N-terminal extracellular region plus a 43aa C-terminal cytoplasmic domain. Over the collective extracellular domains (aa147, 103-118, 184-213 and 274-296), mouse CXCR7 shares 97% and 91% aa identity with rat and human CXCR7, respectively.
Catalog #C8376-25N
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Absorption 620-650nm
Emission 660-670nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. APC is light sensitive.
Clone TypeMonoclonal
IsotypeIgM
Clone No12K75
HostRat
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to mouse CXCR7, extracellular N-terminus and loops, expressed in E.coli.
SpecificityRecognizes mouse CXCR7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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