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You are here:Home » Antibodies » Abs to Nucleotides » Anti -Cyclic GMP (cGMP)

Anti -Cyclic GMP (cGMP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum RIA
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
Catalog #C8451-08
ApplicationsSuitable for use in RIA. Other applications not tested.
Recommended DilutionRIA: 1:800
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder in PBS, pH 7.2. Reconstitute in ddH2O.
PuritySerum
ImmunogenSynthetic human cGMP, polylysine conjugated
SpecificitySynthetic human cGMP, no cross-reactivity with cAMP
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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