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You are here:Home » Antibodies » Antibodies-Cyclin » Anti -Cyclin A

Anti -Cyclin A


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Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH
Cyclins controls the transitions between the phases of the eukaryotic cell cycle as regulatory subunits of the cyclin dependentkinases (cdk). Human cyclins have been grouped into 5 types, A through E, based largely upon sequence similarity. Cyclin A first identified in sea urchin embryos is a 33kD protein identical to adenovirus e1a-associated protein p60. It can bind and activate the kinases p33cdk2 and p34cdc2. In addition to its mitotic functions, cyclin A is essential for progression through S phase. During S phase, cyclin A forms complex containing cdk2, the pRB-related protein p107, and the transcription factor E2F. It may indeed be directly involved in DNA replication; it colocalizes with the DNA replication complex and was found in a cellular activity that promotes large tumor-antigen-dependent simian virus 40DNA replication in Gl-phase cell extracts. It maps to 4q25-q31 region of human chromosome.
Catalog #C8452-06B
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:100-1:500
Immunohistochemistry (formalin fixed paraffin embedded): 1:20-1:40
Optimal dilutions to be determined by the researcher.
Positive ControlHuman lung cell line
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No11E131
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
ImmunogenSynthetic peptide corresponding to the N-terminal fragment of cyclin A protein. Cellular Localization: Nuclear.
SpecificityRecognizes human Cyclin A.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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