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Anti -Cyclin C (Cyclin-C, SRB11 Homolog, hSRB11, CCNC)
Anti -Cyclin C (Cyclin-C, SRB11 Homolog, hSRB11, CCNC)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IF |
|
| Cyclin C was originally identified by a genetic screen for human and Drosophila cDNAs that complement a triple knock-out of the CLN genes in Saccharomyces cerevisiae. Cyclin C is a nuclear protein present in a multiprotein complex. It interacts both in vitro and in vivo with cdk8, a novel protein-kinase of the cdk family. It is suggested that cyclin C and cdk8 control RNA polymerase II function. Human cdk8-cyclin C might be functionally associated with the mammalian transcription apparatus, perhaps involved in relaying growth-regulatory signals. | | | Catalog # | C8453-32B | | Applications | Suitable for use in Immunoprecipitation, Western Blot and Immunofluorescence. Other applications not tested. | | Recommended Dilution | Western Blot: 5ug/ml for 2h, RT | | Immunoprecipitation: 10ug/mg protein lysate | | Optimal dilutions to be determined by the researcher. | | Positive Control | Hela cell, tonsils | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa290-303 from human cyclin C. | | Specificity | Recognizes human cyclin C. Species Crossreactivity: mouse, rat and canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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