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You are here:Home » Antibodies » Abs to Cyclin » Anti -Cyclin D1, CT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia 1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1, PRAD1, PRAD1 Oncogene, U21B31)

Anti -Cyclin D1, CT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia
1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1,
PRAD1, PRAD1 Oncogene, U21B31)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins that are required for cell-cycle progression. Induction of the proto-oncogene cyclin D1, and its binding to CDK4 or CDK6, is a rate-limiting event during cell-cycle progression through G1 phase. Some studies suggested that cyclin D1 also has CDK-independent functions. Studies in zebrafish model showed that cyclin D1 is upregulated by meis1, and it controls several development processes and in some way, carcinogenesis.
Catalog #C8454-01U
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide C8454-01W
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal region of zebrafish Cyclin D1.
SpecificityRecognizes zebrafish Cyclin D1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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