Anti -Cyclin D1, NT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia
1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1,
PRAD1, PRAD1 Oncogene, U21B31)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
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| Regulated progression through the cell cycle requires sequential expression of a family of proteins called cyclins. Upon their induction, cyclins form complexes with specific cyclin-dependent kinases (CDKs), creating active holoenzymes that phosphorylate target proteins that are required for cell-cycle progression. Induction of the proto-oncogene cyclin D1, and its binding to CDK4 or CDK6, is a rate-limiting event during cell-cycle progression through G1 phase. Some studies suggested that cyclin D1 also has CDK-independent functions. Studies in zebrafish model showed that cyclin D1 is upregulated by meis1, and it controls several development processes and in some way, carcinogenesis. | | | Catalog # | C8454-01V | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:5000-1:20,000 | | Western Blot: 1:500-1:1000 | | Optimal dilutions to be determined by the researcher. | | Control Peptide | C8454-01X | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Zebrafish | | Concentration | As reported | | Form | Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the N-terminal region of zebrafish Cyclin D1. | | Specificity | Recognizes zebrafish Cyclin D1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Cyclin D1, NT (CCND 1, CCND1, CCND1 Protein, B-cell CLL/lymphoma 1, B cell Leukemia 1, BCL1, BCL-1 Oncogene, D11S287E, G1/S-specific Cyclin D1, Parathyroid Adenomatosis 1, PRAD1, PRAD1 Oncogene, U21B31) |
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