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You are here:Home » Antibodies » Abs to Cyclin » Anti -Cyclin E1, phosphorylated (Thr395) (G1/S-specific Cyclin-E1, CCNE1, CCNE)

Anti -Cyclin E1, phosphorylated (Thr395) (G1/S-specific Cyclin-E1, CCNE1, CCNE)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Cyclin E1 is a member of the cyclin E family that can associate with and activate cyclin-dependent kinase Cdk2. Expression of cyclin E1 is essential for the control of the cell cycle at the late G1 and early S phase. The cyclin E/Cdk2 complex plays an essential and limiting role in the transition between G1 and S phase as well as the initiation of DNA replication. Ubiquination by the Cul-3 pathway and by Fbw7 regulates cyclin E1 levels and is critically important in normal cells. Abnormally high levels of cyclin E expression have frequently been observed in human cancers. Moreover, high cyclin E1 levels correlate with increased tumor aggression and poor prognosis.
Catalog #C8455-26B
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry:1:50-100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Cyclin E1 around the phosphorylation site of threonine395 (L-L-TP-P-P).
SpecificityRecognizes human Cyclin E1 when phosphorylated at Thr395.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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