Anti -CDKN1B (CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1), KIP1, CDKN4,
P27KIP1, cyclin-dependent kinase inhibitor 1B, p27(KIP1), KIP1, p27)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. | | | Catalog # | C8471-62A | | Positive Control | Human Breast lysate. | | Applications | Suitable for use in ELISA (peptide) and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA (peptide): 1:32000 | | Western Blot: 1-3ug/ml. ~ 26kD band observed in Human Breast and Prostate lysates (calculated MW of 22.1kD according to NP_004055.1). | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris-saline, pH7.2, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide, EQTPKKPGLRRRQT, representing the C Terminus of the human protein according to NP_004055.1. | | Specificity | Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | CDKN1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1), KIP1, CDKN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, p27(KIP1), KIP1, p27 |
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