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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -Cdkn1b, CT (Cyclin-dependent Kinase Inhibitor 1b (P27, kip1), P27-like Cyclin-dependent Kinase Inhibitor, CDKN1B (1 of 3), Dr.75267)

Anti -Cdkn1b, CT (Cyclin-dependent Kinase Inhibitor 1b (P27, kip1), P27-like
Cyclin-dependent Kinase Inhibitor, CDKN1B (1 of 3), Dr.75267)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Cell proliferation is tightly controlled by cyclindependent kinases (CDKs) that function sequentially during the cell cycle. These kinases phosphorylate and thereby regulate key substrates involved in cell cycle progression. The activity regulation of CDKs involve the interaction with additional proteins and post- translational modifications. Essential positive regulators of CDKs are cyclins, the regulatory subunits of cyclin/CDK kinase complexes that are expressed periodically during the cell cycle. Furthermore, CDKs are controlled by phosphorylation that either stimulates or represses catalytic activity. Finally, CDK inhibitors (CKIs) have been shown to interact with distinct cyclin/CDK complexes, thereby interfering with their catalytic activity. p27KIP1 (p27) is a CKI that was originally identified as a protein capable of inhibiting G1 cyclin/CDK complexes. p27 was discovered as a protein whose expression is induced by different growth inhibitory agents, including tumor growth factor beta. Thus, p27 links proliferative and anti-proliferative signals and controls the transition from the G1 into the S phase of the cell cycle.
Catalog #C8471-63M
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Control Peptide C8471-63P
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal region of zebrafish CDKN-1b.
SpecificityRecognizes zebrafish CDKN-1b.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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