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You are here:Home » Biochemicals » Biochem-Steroids » Cyclopamine (11-Deoxyjervine)

Cyclopamine (11-Deoxyjervine)


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Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumor suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle.
Catalog #C8845
Purity 99%
Melting Point 236-238°C
Solubility Chloroform, DMSO (1mg/200ul), hot methanol
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number4449-51-8
Molecular FormulaC27H41NO2
Molecular Weight411.62
FormWhite Crystalline Solid
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user. All goods sold by United States Biological carry the condition that liability for any injury, loss or damage whatsoever to persons or real property resulting from the handling of the said goods lies with the user. Acceptance of our goods binds the customer to these terms.
Alternate names11-Deoxyjervine

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