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Abs to Cyclophilin
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Anti -CYPB (Peptidyl-prolyl cis-trans Isomerase B, PPIase B, CYP-S1, Cyclophilin B, Rotamase B, S-cyclophilin, SCYLP, PPIB)
Anti -CYPB (Peptidyl-prolyl cis-trans Isomerase B, PPIase B, CYP-S1, Cyclophilin B,
Rotamase B, S-cyclophilin, SCYLP, PPIB)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Peptidylprolyl isomerase B, also known as Cyclophilin B and PPIB, is a 216aa containing enzyme with peptidyl-prolyl cis-trans isomerase (PPIase) activity and is associated with the secretory pathways and released in biological fluids. It belongs to the cyclophilin-type PPIase family and PPIase B subfamily with a PPIase cyclophilin-type domain and is usually located in the lumen of endoplasmic reticulum and melanosomes. PPIases accelerate the folding of proteins and are known to catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This cyclosporine-binding protein can also bind to cells derived from T- and B-lymphocytes, and is inhibited by the immunosuppressive drug cyclosporin A (CsA) and is hence an important element in the study of CsA-mediated immunosuppression. Reports also suggest that PPIB is an important component of the HCV replication machinery, acting as a stimulatory regulator of NS5B and could be a possible target for antiviral therapy. | | | Catalog # | C8855-01D | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa100-200 of human Cyclophilin B. | | Specificity | Recognizes human Cyclophilin B. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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