You are here:Home
»
Antibodies
»
Abs to Antibiotics
»
Anti -Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)
Anti -Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E |
|
| Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. The complex of cyclosporin A with cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki270nM). Cyclosporin A inhibits interleukin-1a-, lipopolysaccharide- and TNF-a-nitric oxide synthesis induction. | | | Catalog # | C8900-01 | | Applications | Suitable for use in ELISA. Other applications have not been tested. | | Recommended Dilutions | Optimal dilutions to be determined by the researcher. | | Kd | 1x10e-8 L/mol | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 1.BB.884 | | Host | Mouse | | Concentration | ~2mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Cyclosporin C (BSA coupled). Cyclosporin C is a derivative of Cyclosporin A. | | Specificity | Recognizes Cyclosporin A in buffer solutions and whole blood extracts. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
