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You are here:Home » Antibodies » Abs to Antibiotics » Anti -Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)

Anti -Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E
Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. The complex of cyclosporin A with cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki270nM). Cyclosporin A inhibits interleukin-1a-, lipopolysaccharide- and TNF-a-nitric oxide synthesis induction.
Catalog #C8900-01
ApplicationsSuitable for use in ELISA. Other applications have not been tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Kd 1x10e-8 L/mol
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No1.BB.884
HostMouse
Concentration~2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenCyclosporin C (BSA coupled). Cyclosporin C is a derivative of Cyclosporin A.
SpecificityRecognizes Cyclosporin A in buffer solutions and whole blood extracts.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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