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Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)
Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)
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| Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. The complex of cyclosporin A with cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki 270nM). Cyclosporin A inhibits interleukin-1a-, lipopolysaccharide-, and TNF-a-nitric oxide synthesis induction. | | | Catalog # | C8900-02 | | Solubility | Soluble in DMSO or ethanol | | Loss on Drying | 2% | | Heavy Metals | 0.002% | | Storage and Stability | | | Store tightly sealed in the dark at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | 59865-13-3 | | Molecular Formula | C62H111N11O12 | | Molecular Weight | 1202.64 | | Purity | 99% | | Form | Supplied as a white crystalline powder. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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