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You are here:Home » Biochemicals » Biochem-Antibiotics » Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)

Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)


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Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. The complex of cyclosporin A with cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki 270nM). Cyclosporin A inhibits interleukin-1a-, lipopolysaccharide-, and TNF-a-nitric oxide synthesis induction.
Catalog #C8900-02
Solubility Soluble in DMSO or ethanol
Loss on Drying 2%
Heavy Metals 0.002%
Storage and Stability
Store tightly sealed in the dark at -20°C. Stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number59865-13-3
Molecular FormulaC62H111N11O12
Molecular Weight1202.64
FormSupplied as a white crystalline powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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