Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Biochemicals » Biochem-Antibiotics » Cyclosporin A (Ciclosporin, Cyclorin, Neoral, Ramihyphin A, Sandimmun, Sandimmune, OL 27-400, S 7481F1, CyA, Antibiotic S 7481F1)

Cyclosporin A (Ciclosporin, Cyclorin, Neoral, Ramihyphin A, Sandimmun, Sandimmune, OL
27-400, S 7481F1, CyA, Antibiotic S 7481F1)


  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.


Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism.
Catalog #C8900-04
Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically, cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha -amino-butyryl- N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).
Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number59865-13-3
Molecular FormulaC62H111N11O12
Molecular Weight1202.64
Purity98% as determined by RP-HPLC and MALDI-TOF
FormSupplied as a lyophilized powder without additives. Reconstitute sterile deionized H2O to a concentration 0.1mg/ml, which can then be further diluted to other aqueous solution.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

External Links