Cyclosporin A (Ciclosporin, Cyclorin, Neoral, Ramihyphin A, Sandimmun, Sandimmune, OL
27-400, S 7481F1, CyA, Antibiotic S 7481F1)
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| Cyclosporin A is a noncytotoxic, natural, 11 amino acid cyclic peptide used clinically as an immunosuppressant for the treatment of autoimmune and inflammatory disorders and to prevent organ rejection after transplantation. Cyclosporin acts chiefly by inhibiting T lymphocyte function, which is vital for the propagation of inflammation. Cyclosporin A does not suppress the activity of other hematopoietic cells, does not cause bone marrow suppression and has a rapid onset of action as opposed to other immunosuppressive agents. Nevertheless, Cyclosporin A -induced nephrotoxicity remains an important clinical problem, and oxidative stress has been implicated as a potential responsible mechanism. | | | Catalog # | C8900-04 | | Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nlyea. Chemically, cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha -amino-butyryl- N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl). | | Storage and Stability Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 59865-13-3 | | Molecular Formula | C62H111N11O12 | | Molecular Weight | 1202.64 | | Purity | 98% as determined by RP-HPLC and MALDI-TOF | | Concentration | ~1mg/ml | | Form | Supplied as a lyophilized powder without additives. Reconstitute sterile deionized H2O to a concentration 0.1mg/ml, which can then be further diluted to other aqueous solution. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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