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You are here:Home » Biochemicals » Biochem-Antibiotics » Cyclosporin H

Cyclosporin H

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Specifications

Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclopsorin H is the most extensively investigated of the minor cyclosporin analogues and displays a range of activities. It is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.
Catalog #C8901-11
SourceCyclosporin H from Trichoderma sp.
Molecular Weight~1202.6
SolubilitySoluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number83602-39-5
Molecular FormulaC62H111N11O12
Molecular Weight~1202.6
Purity~95% (HPLC)
ConcentrationNot determined
FormSupplied as a white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.


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