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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -CYP26B1 (Cytochrome P450 26B1, Cytochrome P450 26A2, Cytochrome P450 Retinoic Acid-inactivating 2, Cytochrome P450RAI-2, Retinoic Acid-metabolizing Cytochrome, CYP26A2, P450RAI2)

Anti -CYP26B1 (Cytochrome P450 26B1, Cytochrome P450 26A2, Cytochrome P450 Retinoic
Acid-inactivating 2, Cytochrome P450RAI-2, Retinoic Acid-metabolizing Cytochrome, CYP26A2,
P450RAI2)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B IH
Involved in retinoic acid metabolism by oxidizing retinoic acid into inactive metabolite and is essential for postnatal survival and germ cell development. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Has a preferred activity toward the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells to arrest male germ cells in the G0 phase of the cell cycle and prevent them from entering meiosis.
Catalog #C8929-03H2
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:128,000
Western Blot: 0.1ug/ml
Immunohistochemistry (Paraffin): 4-6ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-SQARSEDKDGRFH, from human CYP26B1, at the internal region of the protein (NP_063938.1).
SpecificityRecognizes human CYP26B1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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