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You are here:Home » Antibodies » Abs to Cytochrome » Anti -CYP17A1 (Cytochrome P450, family 17, subfamily A, polypeptide 1, CPT7, S17AH, Steroid 17-alpha-hydroxylase/17,20 lyase, Steroid 17-alpha-monooxygenase)

Anti -CYP17A1 (Cytochrome P450, family 17, subfamily A, polypeptide 1, CPT7, S17AH,
Steroid 17-alpha-hydroxylase/17,20 lyase, Steroid 17-alpha-monooxygenase)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IC
Cytochrome P450 17A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. It localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in Cytochrome P450 17A1 are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia (1).
Catalog #C8929-03Q
ApplicationsSuitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation. Other applications have not been tested.
Recommended Dilutions
Western Blot: 1:1000-1:10,000
Immunocytochemistry (IF): 1:100-1:250
Immunoprecipitation: 1:10-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone NoEPR6293
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.2, 0.05% BSA, 0.01% sodium azide, 50% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues in human Cytochrome P450 17A1
SpecificityRecognizes human cytochrome. Species crossreactivity: Mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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