Anti -Cystatin A (Stefin A, Cystatin-A, Cystatin-AS, Stefin-A, CSTA, STF1, STFA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| Cystatins are cysteine protease inhibitors constituting a superfamily of evolutionary related proteins, composed of at least one 100-120aa residue domain with conserved sequence motifs. The single-domain human members of this superfamily are of two major types, type 1 and type 2. Cystatin A belongs to family 1 of the cystatin superfamily. It is an inhibitor of lysosomal cysteine proteinases cathepsin B, H, L and S. It was originally isolated from polymorphonuclear granulocytes, but it has also been isolated from the spleen, liver, and epidermis. The gene encoding the protein consists of three exons and two introns. The protein consists of 98aa residues with a molecular mass of 11006D, lack disulfide bridges, and is synthesized without signal peptides. Recent reports reveal that cystatin A is identical to keratolinin, one of the precursor proteins of cornified cell envelope (CE), which is formed during terminal differentiation of keratinocytes. It has been proposed as prognostic and diagnostic tools for cancer. | | | Catalog # | C8949-18C | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Brain | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E138 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Supernatant | | Immunogen | Human Cystatin A. Cellular Localization: Cytoplasmic. | | Specificity | Recognizes human Cystatin A. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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