Cystatin C, Human (AD8, Amyloid Angiopathy and Cerebral Hemorrhage, Cst3, Cystatin 3,
Gamma Trace, HCCAA, Neuroendocrine Basic Polypeptide, Post gamma Globulin)
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| Cystatins are a superfamily of cysteine proteinase inhibitors found in both plants and animals. They comprise a group of proteinase inhibitors, widely distributed in tissues and body fluids, and form tight complexes with cysteine proteases such as cathepsin B, H, L and S. Cystatin C, a secreted molecule of this family, is of interest from biochemical, medicine and evolutionary points of view. Cystatin C, with molecular weight of 13.26kD, is composed of 120 amino acids, lacks carbohydrate and has two disulfide bridges located near the carboxyl terminus. Cystatin C is increased in patients with malignant diseases, and is related to the insufficiency of renal function and appears to be a better marker than creatinine. On the other hand, low levels of cystatin C involve cause the breakdown of the elastic laminae and, subsequently, the atherosclerosis and abdominal aortic aneurysm. | | | Catalog # | C8950-08 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | Optimal dilutions to be determined by researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 0.02M ammonium bicarbonate buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Molecular Weight | 13.26kD | | Source | Human urine | | Purity | ~90% SDS-PAGE | | Form | Supplied as a lyophilized powder from ammonium bicarbonate pH 4.5. May contain traces of buffer salts. Reconstitute in 0.02M ammonium bicarbonate buffer. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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