Cystatin C, Human (AD8, Amyloid Angiopathy and Cerebral Hemorrhage, Cst3, Cystatin 3,
Gamma Trace, HCCAA, Neuroendocrine Basic Polypeptide, Post gamma Globulin)
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| Cystatins are a superfamily of cysteine proteinase inhibitors found in both plants and animals. They comprise a group of proteinase inhibitors, widely distributed in tissues and body fluids, and form tight complexes with cysteine proteases such as cathepsin B, H, L and S. Cystatin C, a secreted molecule of this family, is of interest from biochemical, medicine and evolutionary points of view. Cystatin C, with molecular weight of 13.26kD, is composed of 120aa, lacks carbohydrate and has two disulfide bridges located near the carboxyl terminus. Cystatin C is increased in patients with malignant diseases, and is related to the insufficiency of renal function and appears to be a better marker than creatinine. On the other hand, low levels of cystatin C involve cause the breakdown of the elastic laminae and, subsequently, the atherosclerosis and abdominal aortic aneurysm. | | | Catalog # | C8950-08A | | Source | Cystatin C, from human urine. | | Specific protein | 1.59mg/ml (Aptec Cystatin C Turbidimetric assay) | | Total protein | 1.68mg/ml (OD280nm) | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | Source | Human urine | | Purity | Highly Purified (~95%) | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 25mM Tris HCl, pH 8.0, 150mM sodium chloride, 0.09% sodium azide. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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