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Anti -Cysteine and Glycine-rich Protein 2 (CSRP2, Cysteine-rich Protein 2, CRP2, LIM Domain Only Protein 5, LMO-5, Smooth Muscle Cell LIM Protein, SmLIM, LMO5, SMLIM)
Anti -Cysteine and Glycine-rich Protein 2 (CSRP2, Cysteine-rich Protein 2, CRP2, LIM
Domain Only Protein 5, LMO-5, Smooth Muscle Cell LIM Protein, SmLIM, LMO5, SMLIM)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| CSRP2 (Cysteine-rich protein 2/CRP2; also Cysteine and Glycine-rich protein 2, LMO-5 and SmLIM) is a 21-22kD member of the CRP family of LIM domain-containing proteins. It is expressed in arterial smooth muscle, hepatic stellate cells and fibroblasts. CSRP2 is upregulated by TGF-b and downregulated by PDGF, and appears to interact with PIAS1 and CRP2-BP, thus promoting STAT signaling. It also binds to SRF and GATA4 to initiate smooth muscle differentiation. Human CSRP2 is 193aa in length and contains two 50aa LIM (for lin11/isl1/mec3) domains that contain two zinc-finger motifs (aa10-61 and 119-170), an NLS between aa64-69, and a Gly-rich C-terminus (aa176-187). Full-length human CSRP2 shares 79% aa identity with human CSRP1. | | | Catalog # | C9001-10B | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot:2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute in PBS, 0.02% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Purified, E. coli-derived full-length recombinant human CSRP2 (aa1-193; Accession #Q16527). | | Specificity | Recognizes human CSRP2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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