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You are here:Home » Antibodies » Abs to Infectious Disease CMV » Anti -Cytomegalovirus (CMV)

Anti -Cytomegalovirus (CMV)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH IF
Human cytomegalovirus is a ubiquitous herpes virus. The primary infection usually occurs in childhood where it most often is asymptomatic. After initial exposure, the virus establishes a life-long infection. In neonates, and in immunocompromised individuals, such as AIDS patients and transplant recipients, HCMV can cause severe life-threatening infections, and it is the most common cause of viral birth defects. Antibody CCH2 reacts with an early nuclear protein identical with the non-structural DNA-binding protein p52. Antibody DDG9 reacts with an immediate early nuclear protein of about 76kD. For both antibodies, the reactivity persists also at later stages during the HCMV infection where the localization is less distinctly nuclear and appears to be in the cytoplasm. Laser confocal microscopy, however, shows that the reaction is limited to the nuclear membrane.
Catalog #C9011-01G
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:10-1:25
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Positive ControlInfected lung, human salivary gland
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a+IgG1,k
Clone No11E139
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenCytomegalovirus infected cell lysate. Cellular Localization: Nuclear.
SpecificityRecognizes human immediate early and early Cytomegalovirus at 76kD. Does not crossreact with adenovirus, herpes simplex virus, and varicella zoster virus.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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