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You are here:Home » Antibodies » Abs to Binding Proteins » Anti -CYR61 (Protein CYR61, CCN Family Member 1, Cysteine-rich Angiogenic Inducer 61, Insulin-like Growth Factor-binding Protein 10, IBP-10, IGF-binding Protein 10, IGFBP-10, Protein GIG1, CCN1, GIG1, IGFBP10)

Anti -CYR61 (Protein CYR61, CCN Family Member 1, Cysteine-rich Angiogenic Inducer 61,
Insulin-like Growth Factor-binding Protein 10, IBP-10, IGF-binding Protein 10, IGFBP-10,
Protein GIG1, CCN1, GIG1, IGFBP10)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Cyr61 (Cysteine-rich angiogenic inducer 61), also known as IGFBP-10 and CCN1, is a 42kD secreted matrix- and cell-associated glycoprotein that regulates the growth and adhesion of vascular endothelial cells, fibroblasts, and monocytes. Cyr61 interacts with cells that express integrins avb3, avb5, amb5 and a6b1. Cyr61 is cleaved by plasmin within its VWF domain which generates an N-terminal fragment that is not associated with the matrix but retains the ability to induce endothelial cell migration. Cyr61 induces VEGF upregulation, angiogenesis, and tumorigenesis. Mature human Cyr61 shares 93% aa sequence identity with mouse and rat Cyr61. Cyr61 expression appears to be unregulated in breast cancer cells with high levels of heregulin.
Catalog #C9018-01J
ApplicationsSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:250-1:1000
Immunohistochemistry (FFPE): 5ug/ml. Requires antigen retrieval in 0.01M sodium citrate buffer, pH 6.0.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.    
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No3H3
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by Protein G affinity chromatography
ImmunogenRecombinant protein corresponding to aa168-242 from human CYR61, expressed in E. coli.
SpecificityRecognizes human CYR61.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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