You are here:Home
»
Antibodies
»
Abs to Multi Drug Resistance (MDR)
»
Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, CF, CFTR/MRP, ABC35, ATP-binding Cassette Sub-family C Member 7, ATP Binding Cassette Superfamily C Member 7, ABCC7, cAMP-dependent Chloride Channel, Channel Conductance-controlling ATPase, dJ760C
Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, CF, CFTR/MRP, ABC35,
ATP-binding Cassette Sub-family C Member 7, ATP Binding Cassette Superfamily C Member 7,
ABCC7, cAMP-dependent Chloride Channel, Channel Conductance-controlling ATPase, dJ760C
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
IH |
|
| The cystic fibrosis transmembrane conductance regulator (CFTR) is a unique member of the ATP-binding cassette (ABC) transporter superfamily that plays a critical role in fluid and electrolyte transport across epithelial tissues. It is composed of two membrane-spanning domain (MSD), nucleotide-binding domain (NBD) motifs linked by a unique regulatory (R) domain. The MSDs assemble to form a transmembrane pore with deep intracellular and shallow extracellular vestibules that funnel anions towards a selectivity filter, which determines the permeation properties of CFTR. The R domain contains multiple consensus phosphorylation sites on the surface of an unstructured domain. Phosphorylation of the R domain stimulates CFTR function by enhancing ATP-dependent channel gating at the NBDs. Thus, it is an anion channel with exquisite regulation. The protein also regulates the function of other channels, such as those that transport positively charged particles called sodium ions across cell membranes. These channels are necessary for the normal function of organs such as the lungs and pancreas. It is expressed on the surface of the epithelial cells that line the lungs and other organs. The pathological role of the protein has been observed in cystic fibrosis and congenital bilateral absence of the vas deferens. | | | Catalog # | C9040-05B | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Pancreas | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E140 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Ascites | | Immunogen | Recombinant corresponding to NBF2 domain of human CFTR. Cellular Localization: Cell membrane. | | Specificity | Recognizes human CFTR. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
