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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, CF, CFTR/MRP, ABC35, ATP-binding Cassette Sub-family C Member 7, ATP Binding Cassette Superfamily C Member 7, ABCC7, cAMP-dependent Chloride Channel, Channel Conductance-controlling ATPase, dJ760C

Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, CF, CFTR/MRP, ABC35,
ATP-binding Cassette Sub-family C Member 7, ATP Binding Cassette Superfamily C Member 7,
ABCC7, cAMP-dependent Chloride Channel, Channel Conductance-controlling ATPase, dJ760C

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IP IH
CFTR (cystic fibrosis transmembrane conductance regulator) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
Catalog #C9040-05D
ApplicationsSuitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Frozen): The epitope is sensitive to formaldehyde fixation and tissue processing. Acetone fixation is recommended for frozen sections. Not recommeneded for use in paraffin sections.
Western Blot: 10ug/ml detects a band at 170kD under native conditions
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10B2212
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified
ImmunogenFusion protein containing residues 1197-1480 of human CFTR
SpecificityRecognizes human CFTR. Recognizes an epitope in the ABC transporter 2 domain, specifically to a region between aa1370-1380. Does not react with mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesATP Binding Cassette Transporter Sub-family C Member 7, Cystic Fibrosis Transmembrane Regulator


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