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Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7)
Anti -Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IH |
|
| Cystic Fibrosis Transmembrane Regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD) and one R domain. It is structurally similar to multidrug resistance protein (Mdr1). CFTR is found in the apical membranes of epithelia within the pancreas, intestine, bile duct, sweat gland and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation. | | | Catalog # | C9040-07 | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: 1:50-1:100 for 30 min. at RT (ABC method). For formalin fixed paraffin embedded sections, perform heat mediated antigen retrieval using 10mM citrate buffer pH 6.0 before commencing with the Immunohistochemistry staining protocol. | | Optimal dilutions to be determined by the researcher. | | Positive Control | Pancreas | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 4i360 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS with sodium azide. | | Purity | Purified | | Immunogen | Recombinant protein encoding NBF 2 domain of human CFTR. Cellular Localization: Cell membrane | | Specificity | Reacts with a protein of 165-170kD corresponding to human CFTR. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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