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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Cytochrome P450 1A1, 1A2

Anti -Cytochrome P450 1A1, 1A2

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Specifications

Clone Host Grade Applications
Polyclonal Goat Purified E B IP
Phase 1 drug metabolism is catalyzed by two groups of monooxygenases, the cytochrome P450s (CYPs) and the flavin monooxygenases (FMOs). Both CYPs and FMOs are localized in the endoplasmic reticulum. Collectively, these enzymes catalyze the oxidation of a very broad range of substrates. Both classes are dependent on NADPH as a source of electrons, but the two classes exhibit significant differences in mechanism and substrate specificity.
Catalog #C9095-11E
ApplicationsSuitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 1:50 dilution will yield a positive result with 0.2ug of recombinant human cytochrome P450 1A1 and/or 1A2 using HRP-conjugated rabbit antigoat antibodies according to the manufacturer's instructions.
Optimum dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceRabbit
ConcentrationNot Determined
FormSupplied as a liquid with 0.05% sodium azide before the addition of glycerol to 40%.
PuritySerum
ImmunogenPurified rabbit CYP450 1A1/1A2.
SpecificityRecognizes both forms in liver microsomes prepared from rabbits or rats that were induced to express multiple forms of P450.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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