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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Cytochrome p450 1A2 (CYP1A2) (Biotin)

Anti -Cytochrome p450 1A2 (CYP1A2) (Biotin)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified B
The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid Arachadonic Acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P-450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and -hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). Cytochrome P450 1A2 is involved in the metabolism of imipramine, propranolol, clozapine, theophylline, and caffeine as well as the conversion of many heterocyclic amines to alternate carcinagenic and mutgenic forms, including 17-b-estradiol.
Catalog #C9095-12C1
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000. Detects a band of ~56kD.
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS. Labeled with Biotin. No preservative and no stabilizing proteins added.
PurityPurified
ImmunogenPurified full length human cytochrome P450 (isoform 1A2).
SpecificityRecognizes human cytochrome P450 (1A2 isoforms). Weakly cross-reacts with other P450 isoforms.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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