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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Cytochrome P450 Enzyme CYP1A1 and CYP1A2

Anti -Cytochrome P450 Enzyme CYP1A1 and CYP1A2

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E B
Cytochromes P450 enzymes are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen.
Catalog #C9095-18
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: Useful for the simultaneous detection of CYP1A1 (57kD) and CYP1A2 (54kD), which can be separated electrophoretically.
Optimal dilution determined by the researcher.
Positive ControlRat hepatic microsomal fraction.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceRat
ConcentrationNot determined
FormSupplied as a liquid. No preservative added.
PuritySerum
ImmunogenSynthetic peptide
SpecificityRecognizes rat Cytochrome P450 Enzyme CYP1A1 and CYP1A2 on Western Blots of hepatic microsomal fraction. Does not crossreact with other cytochrome P450 enzymes.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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