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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Cytochrome P450 19A1 (Cytochrome P450 Family 19 Subfamily A Polypeptide 1, CYP19A1, CYP19, CYPXIX, Aromatase, ARO, ARO1, ARO 1, CPV1, CYAR, Estrogen Synthetase, MGC104309, P450AROM, P-450AROM)

Anti -Cytochrome P450 19A1 (Cytochrome P450 Family 19 Subfamily A Polypeptide 1, CYP19A1,
CYP19, CYPXIX, Aromatase, ARO, ARO1, ARO 1, CPV1, CYAR, Estrogen Synthetase, MGC104309,
P450AROM, P-450AROM)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH IF
P450 arom plays an important role in oestrogen biosynthesis and is highly conserved amongst mammals. P450 arom is highly expressed in placental tissue. The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid Arachadonic Acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as mNADPH and P-450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and w-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE).
Catalog #C9095-19W2
ApplicationsSuitable for use in Immunohistochemistry, Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:250. Detects a band at ~55kD. For tissues where there may be low expression of P450 arom, the use of microsomal extracts may improve the staining for Western Blots using this antibody.
Immunohistochemistry: Paraffin sections. Does not require antigen retrieval using heat reatment prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.
HybridomaSp2/0 myeloma cells with spleen cells from Balb/c mice.
Recommended Positive ControlHuman placenta
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No10B2634
HostMouse
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid, 0.1% sodium azide.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to aa376-390 of human aromatase.
SpecificityRecognizes a conserved epitope within human Cytochrome P450 aromatase (P450 arom). Species Crossreactivity: rat, chicken, giraffe, mouse, porcine, baboon, bovine, equine, rabbit, sheep, goat, great fruit eating bat, collared peccary and marmoset.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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