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You are here:Home » Antibodies » Antibodies-Enzymes, Cytochrome » Anti -Cytochrome P450 19A1a, CT (Cyp-19a1a, Aromatase, CYPXIX, Cytochrome P-450AROM, Estrogen Synthase, cyp19a1a, cyp19, cyp19a)

Anti -Cytochrome P450 19A1a, CT (Cyp-19a1a, Aromatase, CYPXIX, Cytochrome P-450AROM,
Estrogen Synthase, cyp19a1a, cyp19, cyp19a)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
Cytochrome p450, family 19 subfamily A polypeptide 1a (Cyp19a1a) was previously known as P450aromA and is one of two isoforms of the aromatase gene. It is the terminal enzyme in the steroidogenic pathway that converts androgens into estrogens. Thus, appropriate expression of the enzyme is essential to both reproduction and sex differentiation. Cyp19a1a is found to be expressed in follicular cells in the ovary during vitellogenesis. One study showed inhibition of cyp19a1a aromatase activity but not transcript abundance when exposed to androstatrienediol. Additionally, expression and aromatase activity of cyp19a1a were inhibited when exposed to estradiol. These results point to the possibility of zebrafish as a model for study of endocrine disrupting molecules.
Catalog #C9095-19Z4
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Control Peptide C9095-19Z5
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the C-terminal region of zebrafish Cyp19a1a.
SpecificityRecognizes zebrafish Cyp19a1a exclusively.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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