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You are here:Home » Antibodies » Abs to Enzymes, Cytochrome » Anti -Cytochrome P450 46A1, CT (CYP46A1, Cholesterol 24-hydroxylase, CH24H, CYP46)

Anti -Cytochrome P450 46A1, CT (CYP46A1, Cholesterol 24-hydroxylase, CH24H, CYP46)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B
CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system.
Catalog #C9095-46
P450 enzymes are divided into two groups steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1.
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:15,000
Western Blot: 1:3,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa sequence 254-270 of human cholesterol 24-hydroxylase protein.
SpecificityRecognizes human cholesterol 24-hydroxylase (CYP46A1).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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