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You are here:Home » Antibodies » Abs to G Proteins » Anti -Cytohesin 1 (B2-1, CLM1, CTH-1, CYTIP, Cytoadhesin 1, D17S811E, Homolog of Secretory Protein SEC7, Pleckstrin Homology Sec7 and Coiled/Coil Domains 1, PSCD1)

Anti -Cytohesin 1 (B2-1, CLM1, CTH-1, CYTIP, Cytoadhesin 1, D17S811E, Homolog of Secretory
Protein SEC7, Pleckstrin Homology Sec7 and Coiled/Coil Domains 1, PSCD1)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IP IF
Cytohesin-1 is a guanine nucleotide exchange factor and an integrin binding protein belonging to a closely related group of proteins known as the cytohesion family. Cytohesin-1 contains 2 domains; a C-terminal, pleckstrin homology (PH) domain, and a central, large Sec7 domain. The PH domain serves to mediate the proteins functional regulation and the reversible membrane recruitment. The Sec7 domain acts as the primary regulator for phosphoinositide-dependent membrane attachment of the protein. Cytohesin-1 appears to have an integral role in integrin alphaLbeta2 adhesive function, and in the activation of integrin mediated pathways involved in wound healing, and immune system cell-cell/ cell-matrix interactions. It is highly expressed in natural killer and peripheral T cells. There are two known isoforms produced by alternative splicing.
Catalog #C9096-05C
Applications
Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionWestern Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat cell lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1k
Clone No10H4
HostRat
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenRecombinant protein corresponding to human Cytohesin-1 (Histidine-tagged).
SpecificityRecognizes human Cytohesin-1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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