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Specifications

Clone Host Grade Applications Monoclonal Mouse B IH IF

Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratin 5, 6 and 8 are members of the type II neutral-to-basic subfamily.Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. PCK-26 facilitates the typing of normal, metaplastic and neoplastic cells and it may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micro-metastases in lymph nodes and other tissues and for determining the origin of poorly differentiated tumors (Lane EB et al,Moll R et al).
Catalog #	C9097-01K
Applications	Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested.
Recommended Dilution	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	8J1152
Host	Mouse
Source	Human
Concentration	As reported
Form	Ascitic fluid with 0.1% sodium azide
Purity	Ascites
Immunogen	Full length native protein (purified) (Human epidermis).
Specificity	Recognizes the 58kD cytokeratin 5, the 56kD cytokeratin 6 and the 52kD cytokeratin 8 band in immunoblotting (Lane EB et al). It reacts specifically with a wide variety of normal, reactive and neoplastic epithelial tissues. The antibody reacts with simple, cornifying and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues. Species Crossreactivity: Crossreacts with Chicken, bovine, Goat, Mouse, Rabbit, Rat, Sheep and a wide range of other species.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.