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Abs to Keratin, Cytokeratin
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Anti -Keratin 10, CT (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, K10, KPP)
Anti -Keratin 10, CT (Keratin, Type I Cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10,
K10, KPP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| Cytokeratin 10 (CK10) belongs to a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non- keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. CK10 is expressed in all suprabasal layers of the epidermis. It is absent in the basal layer, but appears in the first suprabasal layers and increases in concentration towards the granular layer. Expression of CK10 is related to maturation of malignant keratinocytes, preferentially detected in more-differentiated parts. CK10 is also associated with human hepatocellular carcinoma (HCC) invasiveness. CK10 alone, or in combination with CK19, can be a novel predictor for poor prognosis of HCC patients after curative resection. | | | Catalog # | C9097-10E | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH7.4, 0.05% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C-terminus of human Keratin-10. | | Specificity | Recognizes human Keratin-10. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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