Anti -Cytokeratin 18 (Keratin, Type I Cytoskeletal 18, Cell Proliferation-inducing Gene 46
Protein, Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18, PIG46)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
B IP IH IC IF |
|
| Among the cytoplasmic intermediate filaments (IF) proteins, keratins make up the largest family and are expressed specifically in epithelial cells in a cell-specific manner. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant IF protein complement in an epithelial cell-specific manner. Cytokeratin 18 is a type-I keratin that is found in a variety of simple epithelial tissues. Cytokeratin 8 and 18 (K8/18) phosphorylation plays a significant and site-specific role in regulating keratin filament organization, association with binding proteins, and modulation of cell cycle progression. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. It maps to 12q13 region of human chromosome. It is expressed in colon, placenta, liver and very weakly in exocervix. | | | Catalog # | C9097-21F | | Applications | Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:50-1:100 | | Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:75 | | Immunohistochemistry: Frozen | | Optimal dilutions to be determined by the researcher. | | Positive Control | Skin | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E151 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Purified | | Immunogen | PMC-42 human breast carcinoma cell line. Cellular Localization: Cytoplasmic. | | Specificity | Recognizes human Cytokeratin 18. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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