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You are here:Home » Antibodies » Abs to Cytokeratin » Anti -Cytokeratin 18 (Keratin, Type I Cytoskeletal 18, Cell Proliferation-inducing Gene 46 Protein Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18, PIG46)

Anti -Cytokeratin 18 (Keratin, Type I Cytoskeletal 18, Cell Proliferation-inducing Gene 46
Protein Cytokeratin-18, CK-18, Keratin-18, K18, KRT18, CYK18, PIG46)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IH IF
Intermediate filaments (IFs) are a structurally related family of cellular proteins that appear to be intimately involved with the cytoskeleton. Human keratin 18(KRT18) and the homologous mouse Endo B are type I IF protein subunits whose expression is restricted in adults to a variety of simple epithelial tissues. The KRT18 gene is 3,791 bp long and the keratin 18 protein is coded for by 7 exons. The K18 gene is 3791 bp in length and the K18 protein is coded for by seven exons. By Southern blotting using the genomic DNA PCR product, the gene for keratin 18 is assigned to chromosome 12. Mutation of human keratin 18 in association with cryptogenic cirrhosis.
Catalog #C9097-23A
ApplicationsSuitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, and Immunofluorescence. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-1ug/ml
Immunohistochemistry (paraffin): 1-2ug/ml
Immunohistochemistry (frozen): 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10K180
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from 1.2% sodium acetate, 2mg BSA, 0.01mg sodium azide. Reconstitute with 1.2% sodium acetate, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenHuman epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.
SpecificityRecognizes human Cytokeratin 18. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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