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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified B IC

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. Cytokeratin 1 has the highest molecular weight and the highest isoelectric pH, while cytokeratin 19 has the lowest molecular weight and a low isoelectric pH. The cytokeratins are divided into the type I and type II subgroups, the type II family members comprising the basic to neutral cytokeratins 1-8, while the type I group comprises the acidic cytokeratins 9-20. The cytokeratins are expressed in combinations which characterize the type of epithelium. Cytokeratin 19 is the smallest human cytokeratin (40kD) and is found in many simple and invariably in some non-keratinizing stratified squamous epithelia. All adenocarcinomas tested have been positive for cytokeratin 19.
Catalog #	C9097-28E
	Fusion Partner Px63 Ag 8.653 myeloma cell line
	Source Tissue culture supernatant
Applications	Cytokeratin 19 positive detection distinguishes malignant from benign breast tumors. Suitable for use in Immunocytochemistry, Western blotting, Immunohistochemistry (staining frozen and paraffin wax embedded tissue sections after proteolytic enzyme digestion).
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	2Q1032
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as supernatant in PBS, 10mM sodium azide and 1mg/ml bovine serum albumin
Purity	Protein A affinity chromatography
Immunogen	Human reduction mammoplasty organoid
Specificity	The antibody is specific to human cytokeratin 19 and is reactive with cells of epithelial origin.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.