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You are here:Home » Antibodies » Abs to Cytokeratin » Anti -Cytokeratin 5 (CK 5, CK5, CK-5, 58kD Cytokeratin, DDD, EBS 2, EBS2, Keratin 5 (Epidermolysis Bullosa Simplex Dowling Meara/Kobner/Weber Cockayne Types), Keratin-5, Keratin Type II Cytoskeletal 5, K5, KRT5, KRT5A)

Anti -Cytokeratin 5 (CK 5, CK5, CK-5, 58kD Cytokeratin, DDD, EBS 2, EBS2, Keratin 5
(Epidermolysis Bullosa Simplex Dowling Meara/Kobner/Weber Cockayne Types), Keratin-5,
Keratin Type II Cytoskeletal 5, K5, KRT5, KRT5A)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Guinea pig Serum B IH
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (ie., mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. At least 20 different cytokeratins (CK) in the molecular range of 40 to 70kD and isoelectric points of 5 to 8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Defects in KRT5 are a cause of epidermolysis bullosa simplex.
Catalog #C9097-37
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Frozen): 1:100, Incubation time 1hr at RT.
Immunohistochemistry (Paraffin): 1:50, Incubation time >1hr at RT.
Western Blot (ECL): 1:5000-1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGuinea pig
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 0.5% BSA, 0.09% sodium azide.
PuritySerum
ImmunogenRecombinant human cytokeratin 5
SpecificityRecognizes human basic cytokeratin 5 (Mr 58,000), expressed in the basal and suprabasal layers. Recognizes basal cells of the larynx, esophagus, trachea, bladder, prostate, cervix, vagina, breast acini, skin and sweat glands. Species Crossreactivity: bovine and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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