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Specifications

Clone Host Grade Applications Monoclonal Mouse Supernatant IH

Keratin is a family of about 20 proteins that form intermediate filament in epithelial cells. Obligate heteropolymers of a type I and a type II subunit, they contribute to the structure and strength of the cytoskeleton. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Cytokeratin 5 is a type-II keratin, specifically expressed in the basal layer of the epidermis with family member KRT14. The pathological role of cytokeratin 5 has been identified in epidermolysis bullosa simplex, epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) and Dowling-Degos disease. It maps to 12q12-q13 region of human chromosome. Cytokeratin 14 belongs to the acidic or type I keratin family. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in this gene results in epidermolysis bullosa simplex, epidermolysis bullosa simplex Dowling-Meara type, epidermolysis bullosa simplex Weber-Cockayne type, and Naegeli-Franceschetti-Jadassohn syndrome. It is strongly expressed in the outer root sheath of anagen follicles and found in keratinocytes surrounding the club hair during telogen. It is encoded on chromosome 17q12-q21.
Catalog #	C9097-37R1
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:75
	Optimal dilutions to be determined by the researcher.
Positive Control	human tonsil
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Clone No	11E160
Host	Mouse
Source	Human
Concentration	Not determined.
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Supernatant
Immunogen	Prokaryotic recombinant corresponding to 103aa portion of C-terminal region of the human cytokeratin 5. Cellular Localization: Cytoplasmic.
Specificity	Recognizes human Cytokeratin 5, 14.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.