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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified IH

Keratin is a family of about 20 proteins that form intermediate filament in epithelial cells. Obligate heteropolymers of a type I and a type II subunit, they contribute to the structure and strength of the cytoskeleton. Keratins include more than 20 unique gene products (termed K1-K20) that are divided into type I (K9-K20) and type II (K1-K8). Most epithelial cells express at least one type I and one type II keratin as their predominant intermediate filament protein complement in an epithelial cell-specific manner. Cytokeratin 5 is a type-II keratin. It is specifically expressed in the basal layer of the epidermis with family member KRT14. The pathological role of cytokeratin 5 has been identified in epidermolysis bullosa simplex, epidermolysis bullosa simplex Dowling-Meara type (DM-EBS) and Dowling-Degos disease. It maps to 12q12-q13 region of human chromosome. Cytokeratin 6 is a type-II keratin. It exists in six different isomeric forms which associate with KRT16 and/or KRT17. Mutations in this gene have been associated with pachyonychia congenita. It maps to 12q12-q13 region of human chromosome. It is expressed in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia.
Catalog #	C9097-37V1
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50
	Optimal dilutions to be determined by the researcher.
Positive Control	Skin
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	11E161
Host	Mouse
Source	Human
Concentration	As reported
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Purified
Immunogen	Cytokeratin 5. Cellular Localization: Cytoplasmic.
Specificity	Recognizes human Cytokeratin 5, 6.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.