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You are here:Home » Antibodies » Abs to Cytokeratin » Anti -Cytokeratin 8, phosphorylated (Ser74) (Cytokeratin-8, CK 8, CK8, CK-8, Cyk8, Keratin 8, Keratin-8, K8, KRT8, Keratin Type II, Cytoskeletal 8, K2C8, Keratin, Type II Cytoskeletal 8)

Anti -Cytokeratin 8, phosphorylated (Ser74) (Cytokeratin-8, CK 8, CK8, CK-8, Cyk8, Keratin
8, Keratin-8, K8, KRT8, Keratin Type II, Cytoskeletal 8, K2C8, Keratin, Type II
Cytoskeletal 8)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IF
Cytokeratin 8 (CK8), also known as Keratin 8 (K8), is a type II keratin. Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, and can also be synthesized in certain non-epithelial cells. Cytokeratin 8 mRNA was abundant in fetal small intestine, placenta, pancreas, lung, liver, and kidney. Levels of cytokeratin 8 mRNA in placenta increased slightly during pregnancy. He et al. (2002) presented evidence that K8 is a new cytoplasmic target for JNK in Fas receptor-mediated signaling. The functional significance of this phosphorylation could relate to regulation of JNK signaling and/or regulation of keratin dynamics.
Catalog #C9097-42B2
ApplicationsSuitable for use in Immunofluorescence. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:100-1:200
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to human Keratin 8 around the phosphorylation site of serine 74 (L-L-SP-P-L).
SpecificityRecognizes human Keratin 8 when phosphorylated at serine 74.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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