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You are here:Home » Antibodies » Antibodies-Cytokeratin » Anti -Cytokeratin, pan

Anti -Cytokeratin, pan


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Clone Host Grade Applications
Polyclonal Guinea pig Serum B IH IC
Cytokeratin filaments consist of a complex family of approximately 20 different cytokeratin polypeptides with relative molecular weights of 40kD to 68kD. These intracellular intermediate filaments of 10nm in diameter provide structural integrity to epithelial cells. All the filament subunits share a general common fibrillar organization, consisting of a central alpha-helical rod that is flanked by N- and C-terminal domains at each end. Generally, low molecular weight keratins are expressed in the early stages of cell development, whereas high molecular weight keratins are expressed in maturing cells. This antibody may be useful in determining if a neoplasm originated from an epithelial or non-epithelial source, and is especially useful for the distinction of metastatic malignant tumors of epithelial origin.
Catalog #C9097-48B
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1:2000
Immunohistochemistry (Frozen): 1:100. Incubate for 1hr at RT.
Immunohistochemistry (Paraffin): 1:50. Incubate for >1hr at RT.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGuinea pig
ConcentrationNot Determined
FormSupplied as a liquid, 0.09% sodium azide.
ImmunogenSynthetic peptides corresponding to human keratins.
SpecificityRecognizes most acidic (K1, K4, K8) and basic (K14) human cytokeratins (Mr 40,000-Mr 68,000 polypeptides).
Tumors Specifically DetectedAll types of epithelia and epithelium-derived neoplasms. Species Crossreactivity: mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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