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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari)

Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B IP IH IC
Dab1 is a protein arising from the mouse gene dab, that is related to the Drosophila gene ‘disabled’. Mutations in the mouse dab gene may result in the ‘scrambler’ and ‘yotari’ phenotypes. Dab encodes a phosphoprotein that binds non-receptor tyrosine kinases and has been implicated in neuron development. Dab1 is expressed in neuronal populations exposed to reelin, as determined by in situ hybridization to embryonic mouse brain tissue. Dab1 may function as a signaling molecule that regulates positioning in the developing brain. Cloning of human DAB1 and sequence determinations suggests a 96% homology to the mouse sequence. Very low density lipoprotein receptors (VLDLR) and apolipoprotein E receptor-2 (APOER2) both bind Dab1 on their cytoplasmic tails. Dab1 expression is upregulated in knockout mice lacking both Vldlr and Apoer2 genes.
Catalog #D0900
Applications
Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation. Other applications have not been tested.
Recommended DilutionsWestern Blot: 1:1000-1:5000
Immunocytochemistry: 1:500-1:1000
Immunohistochemistry (fFozen): 1:5000-1:20,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot Determined
FormSupplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
PuritySerum
ImmunogenHighly purified Fusion Protein corresponding to residues 400-555 of mouse Dab1
SpecificityRecognizes mouse Dab1. Does not crossreact with human or mouse Dab2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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