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Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari)
Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IH |
|
| Dab1 is a protein arising from the mouse gene dab, that is related to the Drosophila gene disabled. Mutations in the mouse dab gene may result in the 'scrambler' and 'yotari' phenotypes.Dab1 encodes a phosphoprotein that binds non-receptor tyrosine kinases and has been implicated in neuron development. Dab1 is expressed in neuronal populations exposed to reelin, as determined by in situ hybridization to embryonic mouse brain tissue. Dab1 may function as a signaling molecule that regulates positioning in the developing brain. Cloning of human Dab1 and sequence determinations suggests a 96% homology to the mouse sequence. Very low density lipoprotein receptors (VLDLR) and apolipoprotein E receptor-2 (APOER2) both bind Dab1 on their cytoplasmic tails. Dab1 expression is upregulated in knockout mice lacking both Vldlr and Apoer2 genes. In humans, Dab1 has been mapped to lp32-p312. This region shows homology of synteny with the segment of mouse chromosome 4 containing Dab1. | | | Catalog # | D0900-14A | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (Fr). Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid in PBS containing sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to the C-terminal region of murine Dab1 at amino acid 400-555. | | Specificity | Recognizes mouse Dab1 (Mr 80kD). Expected to crossreact with human due to sequence homology. Does not show reactivity with Dab2. | | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot, Yotari |
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