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You are here:Home » Antibodies » Abs to Neuroscience » Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot)

Anti -Dab1 (Disabled homolog 1 Drosophila, Scm, Scr, Scrambler, Yot)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B
Disabled-1 (Dab1) regulates laminar organization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abnormalities in neuronal positioning, migratory behavior linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adaptor in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral cortex and cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) (3).
Catalog #D0900-14F
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-2000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E258
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues surrounding serine 491 of human Dab1.
SpecificityRecognizes human Dab1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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