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You are here:Home » Antibodies » Abs to Neuroscience » Anti -DACT1 (Dapper Homolog 1, hDPR1, Hepatocellular Carcinoma Novel Gene 3 Protein, DPR1, HNG3)

Anti -DACT1 (Dapper Homolog 1, hDPR1, Hepatocellular Carcinoma Novel Gene 3 Protein, DPR1,
HNG3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
DACT1 is a 836aa protein belonging to the Dapper family. It antagonizes Wnt signaling by promoting DVL2 (Dishevelled) degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism and the interaction is formed between the DEP (Dishevelled, Egl-10, and pleckstrin) domain of Dvl and the central and C-terminal regions of DCT1. Wnt signaling plays a key role in embryogenesis and its dysregulation leads to cancer development. It binds to DVL2 and causes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. DCT1 is required for normal notochord formation and is downregulated in hepatocellular carcinomas (HCC). It is expressed in liver and various other tissues.
Catalog #D1055-02
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa32-49 (REKGEADTERQRTRERQE) of human DACT1.
SpecificityRecognizes human DACT1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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