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DAPT (N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester)
DAPT (N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester)
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| Cell permeable. A potent inhibitor of g-secretase (IC 5nM for total b-amyloid, IC = 200 nM for b-amyloid 1-42). It reduces Ab levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling. | | | Catalog # | D1065-95 | | Solubility | DMSO (~20mg/ml) | | Molecular Weight | ~432.46 | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 208255-80-5 | | Molecular Formula | C H F N O | | Molecular Weight | ~432.46 | | Purity | ~98% (TLC) | | Form | Supplied as a white to off-white solid. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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