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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -DARPP32, phosphorylated (Thr34) (DARPP-32, Dopamine- and cAMP-regulated Neuronal Phosphoprotein, FLJ20940, Protein Phosphatase 1 Regulatory Subunit 1B, PPP1R1B)

Anti -DARPP32, phosphorylated (Thr34) (DARPP-32, Dopamine- and cAMP-regulated Neuronal
Phosphoprotein, FLJ20940, Protein Phosphatase 1 Regulatory Subunit 1B, PPP1R1B)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
DARPP-32, a dopamine (DA) and cAMP-regulated ~32kD phosphoprotein that is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.
Catalog #D1075-03B
ApplicationsSuitable for use in Western Blot.. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlForskolin incubated rat caduate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 10mM HEPES (pH 7.5), 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic phosphopeptide corresponding to amino acids residues surrounding the phosphorylated (Thr34) of DARPP-32.
SpecificityRecognizes human DARPP-32, phosphorylated at (Thr34). Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesProtein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B


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