Anti -Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal,
DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B |
|
| DAZL is involved in mitosis and meiosis of human germ cells. The DZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DZL transcripts were found to be lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DZL homologous gene function found to be azoospermic, just as with human azoospermia. | | | Catalog # | D2675-02C | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.1-0.3ug/ml | | ELISA: >1:64,000 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human Ovary lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to C-GNGPQKKSVDR, from the internal region of the protein sequence according to NP_001342.2. | | Specificity | Recognizes human DAZL. Species sequence homology: mouse, rat, canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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